In a previous study, it was revealed that HBV could induce the production of cancer stem cells (CSCs)-related markers (CD133, CD117, and CD90) and CSCs-related genes (Klf4, SOX2, Nanog, c-Myc, and Oct4) and facilitate the self-renewal of CSCs in human hepatoma cells [15]. This evidence concerns the gene SOX2 and hepatocellular carcinoma.