PARP1 and cancer: Using this assay, another student of mine, Thomas Zaremba, set out to study PARP1 genomics, expression and activity in healthy volunteers and cancer patients with the aim of determining a) whether PARP genotype contributed to reduced PARP activity and the likelihood of developing cancer and b) whether PARP1 genotype, expression or activity contributed to unexpected toxicities in patients treated with temozolomide or radiotherapy.