BRCA2 and neoplasm: The in vivo experiments in mice bearing BRCA1 mutant (MDA-MB-436) or BRCA2 mutant (Capan-1) xenografts, conducted by Yvette Drew and Evan Mulligan, showed that rucaparib caused significant tumour growth delay and this was more pronounced when the treatment period was 5x weekly for 6 weeks compared with daily x10.