PARP1 and cancer: These samples were used to determine the rucaparib PK and also PARP1 genotype, protein levels and inhibition by rucaparib in the patients’ PBMCs (lymphocytes).She also undertook studies in a panel of BRCA wt and mutant human cancer cell lines to confirm the differential sensitivity we had seen in the matched Chinese hamster cells (AA8/irs1SF and V-C8/V-C8.B2).