Here, CD3 density and PD-1 expression in both tumor areas (CT, IM) showed a significant impact on both DFS and OS (CD3: CT, p = 0.018/IM, p = 0.002 and PD-1: CT, p = 0.037/IM, p = 0.016, respectively), whilst PD-L1 expression showed a trend towards improved survival (PD-L1: CT, p = 0.087/IM, p = 0.078); with regard to CD8 density, only expression in the IM was associated with improved survival. The gene discussed is CD274; the disease is neoplasm.