Analysis of irradiated vs. treatment-naïve RC samples applying this methodology showed significantly less CD3 and CD8 T cell density in irradiated RC samples at the invasive margin (p < 0.0001 each, Figure 1B); again, no significant differences were found between CD3 and CD8 density in the central tumor (p = 0.864 and p = 0.227, respectively). Here, CD8A is linked to neoplasm.