In addition, high PD-L1 expression in the central tumor as well as at the invasive margin correlated with a lower Dukes stage (PD-L1: CT: R = –0.23, p = 0.046; IM: R= –0.24, p = 0.041; Table 1, Table 2, Table 3 and Table 4). The gene discussed is CD274; the disease is neoplasm.