Similarly, analysis of irradiated vs. treatment-naïve RC samples using 6 cores from each tumor area showed significantly less CD3 and CD8 T cell density in irradiated RC samples at the invasive margin (p < 0.0001 each, Figure 1C); no significant differences were found between CD3 and CD8 density in the central tumor (p = 0.202 and p = 0.424, respectively). This evidence concerns the gene CD8A and neoplasm.