Heterogeneous clustering of CD3 and CD8 positive T cells, as well as PD-1 and PD-L1 positive TILs was evident; however, evaluation by board-certified pathologists ensured that these heterogeneous expression patterns were seen in the context of the entire tumor section, whilst digital quantification on selected tissue cores would not have allowed any conclusions to be drawn regarding the spatial structure of the tumor. This evidence concerns the gene CD8A and neoplasm.