They found an increased number of intracellular autophagosomes, the transformation of LC3B-I to LC3B-II, Beclin 1, and the upregulation of the rates of phosphorylated mTOR expression with the combination of wogonin and icotinib, which suggests that the combination has inhibitory synergistic effects on cell proliferation and could contribute to apoptosis and autophagy in EGFR T790M-mutated lung cancer [163]. Here, MAP1LC3B is linked to lung cancer.