Some of the potent inhibitors identified to arrest HCC cells were ULK1 small molecule inhibitor (SBI-0206965), the PI3K/mTOR inhibitor (BEZ235), and it was further found that SBI-0206965 and everolimus or BEZ235 synergized with the mTOR inhibitor to kill HCC cells [133]. The gene discussed is ULK1; the disease is hepatocellular carcinoma.