In several HCC cells, the overactivation of the Janus tyrosine kinase (JAK)/signal transducers and activators of transcription (STAT), PI3K/protein kinase B (Akt), and Ras/extracellular signal-regulated kinase (ERK) pathways confer resistance to apoptotic stimuli on them [41]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.