The miR181 was identified as an inhibitor of renal fibrosis via Egr1 inhibition, which suppressed the expression levels of alphaSMA (ACTA2), connective tissue growth factor (CTGF), collagen type I (COL1A1), and type III collagen (COL3A1) in NRK49F cells [90]. This evidence concerns the gene EGR1 and renal fibrosis.