Polymorphisms of XRCC1 rs25487 (c.1196A > G; https://www.ncbi.nlm.nih.gov/snp/rs25487) (odds ratio/OR 3.72, 95% confidence interval/CI 1.739-7.891) and PARP1 rs1136410 (OR 4.159, 95% CI; 1.978−8.745) are significantly associated with AD risk [212]. This evidence concerns the gene XRCC1 and Alzheimer disease.