CD274 and esophageal squamous cell carcinoma: ORR in the whole population was 9.9% (95% CI, 5.2–16.7), 14.3% (95% CI, 6.7–25.4) among ESCC, and 5.2% (95% CI, 1.1–14.4) among EAC, with an inversed proportion with respect to what was observed in phase Ib regarding to the PD-L1 status, with 13.8% (95% CI, 6.1–25.4) of complete and partial responses being observed among PD-L1-positive tumors and 6.3% (95%CI, 1.8–15.5) among PD-L1-negative tumors.