Other diseases have been associated with iron overload, the consequent activation of HIF-α, and the further decrease of hepcidin expression, including HCC, with increased risk in specific populations, mainly in those carrying the mutation C282Y in the HFE gene (homeostatic iron regulator), which leads to higher hepatic iron deposition and serum ferritin [155,156,157]. This evidence concerns the gene HFE and Tangier disease.