On the other hand, activation of α2-AR with dexmedetomidine, α2-AR agonist attenuates renal cell apoptosis and renal tubule impairment by inhibiting mitochondrial apoptosis pathways in the sepsis- or I/R-induced injury model, which may be effective by regulating NE release [147,148,149]. The gene discussed is ADORA2A; the disease is Sepsis.