The identification of the components of the cargo of EVs responsible for triggering neuroinflammation, the TNFα-TNFR1- NF-κB-glutaminase-GAT3 pathway and motor incoordination in hyperammonemia and of the underlying mechanisms will allow understanding in great detail the pathological events responsible for motor incoordination. This evidence concerns the gene TNFRSF1A and Hyperammonemia.