Induction of motor incoordination by chronic hyperammonemia is due to increased TNFα in cerebellum, which activates its receptor TNFR1, leading to increased NF-κB in microglia and glutaminase, which increases GAT3 in activated astrocytes and GABAergic neurotransmission, leading to motor incoordination [9]. The gene discussed is TNF; the disease is Hyperammonemia.