The identification of the components of the cargo of EVs responsible for triggering neuroinflammation, the TNFα-TNFR1- NF-κB-glutaminase-GAT3 pathway and motor incoordination in hyperammonemia and of the underlying mechanisms will allow understanding in great detail the pathological events responsible for motor incoordination. The gene discussed is NFKB1; the disease is Hyperammonemia.