By contrast, in vivo exploration of mice with adenine-induced CKD disclosed low amplitude PER2:luciferase rhythms in their central suprachiasmatic nucleus circadian clock and in intact kidney, liver, and submandibular gland, as well as altered expression patterns of circadian genes including canonical clock genes and kidney genes such as Hif, Aqp2, and V2r [21]. This evidence concerns the gene CLOCK and chronic kidney disease.