HSF1 and central nervous system cancer: We have previously investigated the role of the HSF1/HSP70/BAG3 pathway in resistance of glioma cells to apoptosis-induction with the BH3 mimetics AT-101 and ABT-737 and could demonstrate that pharmacological inhibition of BAG3 (applying the HSF1 inhibitor KRIBB1 and the HSP70/BAG3 interaction inhibitor YM-1) and genetic silencing of BAG3 expression efficiently increased BH3 mimetic-induced cell death and reactivated apoptosis in glioma cells.