In conclusion, the regionalized GENOMEX diet significantly improved body composition and reduced the frequency of subjects with IR, hypertriglyceridemia and elevated VLDL-c; a more significant favorable effect on HOMA-IR and insulin was observed in MTHFR 677T adaptive allele carriers, but no other DRAG polymorphisms were associated with the clinical and biochemical changes in response to the diet. This evidence concerns the gene INS and hypertriglyceridemia.