MTHFR and hypertriglyceridemia: In conclusion, the regionalized GENOMEX diet significantly improved body composition and reduced the frequency of subjects with IR, hypertriglyceridemia and elevated VLDL-c; a more significant favorable effect on HOMA-IR and insulin was observed in MTHFR 677T adaptive allele carriers, but no other DRAG polymorphisms were associated with the clinical and biochemical changes in response to the diet.