After adjustment of the results for smoking status, waist circumference, hypertension, microalbuminuria, the TG/high-density lipoprotein (HDL) ratio, C-reactive protein (CRP), and the homeostasis model assessment of insulin resistance (HOMA-IR) index, the statistical significance of the link between CVD incidence and leptin and adiponectin levels disappeared. The gene discussed is ADIPOQ; the disease is Insulin resistance.