IL6R and myocardial ischemia: A large-scale analysis of 34 genetic studies, including 25,458 cases of IHD and 100,740 control cases of polymorphisms of the IL-6-R gene with cardiac events, revealed that polymorphism rs7529229 in IL6R, which is associated with elevated blood plasma levels of soluble IL-6-R, and lower levels of CRP correlate with lesser frequency of coronary artery diseases [67].