To develop new neuronal and astrocytic models for Sanfilippo C syndrome, we differentiated iPSC lines into induced neurons (iNs) and induced astrocytes (iAs) using lentiviral overexpression of Ngn2 (iNs) or Sox9 and Nfib (iAs) as previously described [31,32]. This evidence concerns the gene SOX9 and mucopolysaccharidosis type 3C.