Tumors of HFD-fed mice increased their expression of proliferation-promoting cyclin D1, β-catenin, Src phosphorylation, Akt phosphorylation, and Smad phosphorylation when compared with tumors in ND-fed mice, with the changes in tumor-bearing HFD-fed mice being reversed by aspirin (Figure 5C). The gene discussed is CCND1; the disease is neoplasm.