Interestingly, cancer-associated exosomes transport many functional proteins such as endosomal network proteins, which include (i) membrane transport and fusion proteins (GTPases, annexins, Rab proteins, and flotillin), (ii) heat-shock proteins (HSPs60, 70, and 90), (iii) multivesicular bodies (MVBs) biogenesis proteins (Alix and TSG101), (iv) cytoskeletal proteins (actin, tubulin, syntenin, and moesin), (v) lipoproteins and phospholipases, (vi) metabolic enzymes, and (vii) signal transduction proteins and major histocompatibility complement antigens [124,125,126,127]. Here, TSG101 is linked to cancer.