Interestingly, cancer cells overexpress different EV-associated biogenesis machinery, such as components of the Endosomal Sorting Complex Required for Transport (ESCRT), syntenin, heparanase, YKT6, amplifying Rho/ROCK, EGFRvIII, H-RASV12, and proto-oncogene Src signaling, which subsequently causes the release of a significantly higher quantity of exosomes than normal cells would release [39,40,41,42,43,44,45,46,47,48]. Here, SDCBP is linked to cancer.