Tumor-intrinsic upregulation of β-catenin signaling induces down-regulation of the chemoattractants CCL4 [20] and CCL5 [104] in both mice and humans, and is associated with reduced cDC1 and CD8+ T cell infiltration, increased tumor growth [20,104], and resistance to anti-PD1 therapy [104]. The gene discussed is CCL5; the disease is neoplasm.