TERT promoter mutations occur mainly in cancers arising from tissues with low-rates of self-renewal that include glioblastoma, melanoma, urothelial carcinoma, squamous cell carcinoma, medulloblastomas, and aggressive thyroid carcinoma subtypes [12,131,136,137,138,139,140,141,142,143]. This evidence concerns the gene TERT and glioblastoma.