Other somatic TERT promoter mutations that create identical binding sites for ETS/TCF transcription factors include that detected at −57 bp, originally discovered as the causal germline mutation in a melanoma pedigree, and at −124/−125 bp and −138/−139 bp as CC > TT tandem mutations that occur mainly in skin cancers [130,132,133,134]. The gene discussed is TERT; the disease is melanoma.