CASP3 and retinal ischemia: Therefore, we plan to investigate possible antiapoptotic mechanism of 2-ethyl-3-hydroxy-6-methylpyridine nicotinate, specifically, p53 activity, Bcl-2, caspase-3, and Nf-kB activity in the correction of retinal ischemia–reperfusion and NMDA-induced excitotoxicity in the retina.