ASH1L and facioscapulohumeral muscular dystrophy: In particular, DBE-T-mediated ASH1L recruitment to D4Z4 in FSHD cells is reported to mediate histone H3 lysine 36 dimethylation (H3K36me2), a major histone mark associated with transcriptional activation, leading to chromatin remodeling and 4q35 gene transcription [43].