The excretion level of CDH1 increased towards nephropathy, it ranges from 18.6 ± 8.7 ng/mL by healthy controls and increased significantly (>45 ng/mL) for DM patients at risk to develop nephropathy and to 77.8 ± 55.2 ng/mL for DN Macro (Figure 5). This evidence concerns the gene CDH1 and diabetes mellitus.