CDH1 and kidney disorder: When modeling the renal function as described by eGFR as function of the urinary albumin excretion as well as CDH1 using a linear mixed model accounting for the clustered data structure within patient (Table 5), CDH1 is significantly related to the eGFR parameter (p < 0.05), whereas the urinary albumin shows no correlation with eGFR in early stages of nephropathy (Table 5, Supplementary Figure S3A).