In the small cohort the data showed a significant up-regulation of CDH1 expression in the DN group compared to the other three groups (Supplementary Figure S4A), whereas in large group no significant regulation of CDH1 was observed (Supplementary Figure S4B) revealing that issue of the expression regulation of CDH1 in diabetic nephropathy still needs further investigations. This evidence concerns the gene CDH1 and liver dysplastic nodule.