Moreover, soluble E-cadherin in serum serves as cancer prognostic marker [42] and the soluble fragment in urine corresponds to the 80 kDa ectodermal fragment of the protein, which can be cleaved by several proteases including plasmin, MMP3, MMP7, ADAM10, and ADAM-15 [43,44,45]. The gene discussed is ADAM10; the disease is cancer.