HMOX1 and Hyperglycemia: This finding is in line with previous data pointing out that: (1) NF-κB represents one of the most common intracellular targets of hyperglycemia [60], and its translocation to the nucleus regulates the expression of several factors including pro-inflammatory cytokines [61]; (2) Nrf2, a transcription factor that is involved in the regulation of ROS-sensitive genes during oxidative stress events, translocates to the nucleus [62] allowing the transcription of genes directly involved in the protection against oxidative stress such as HO-1 [63].