For example, CXCR2 is highly upregulated in tumour recruited neutrophils and MDSCs, and abrogation of CXCR2 signalling significantly improved T-cell infiltration and extended survival in both cancer patients and mice models [118], especially in combination with other immune checkpoint blockades such as PD-1 treatments [150,159]. This evidence concerns the gene CXCR2 and neoplasm.