NOS2 and ovarian neoplasm: In ovarian tumors, PRLR activation may also result in further induction of inflammatory mediators such as NF-kappa B, which plays a central role in inflammation by regulation of genes encoding for proinflammatory cytokines, adhesion molecules, chemokines, growth factors, COX2, and inducible nitric oxide synthase (iNOS) [54,55,56].