TEA domain transcription factor 4 (TEAD4) cooperates with activator protein 1 (AP-1) in the chromatin of endometrial cancer cells and establishes an interaction between ERα and progesterone receptor (PR) in breast cancer cells [39,40], transcription factor 12 (TCF12), also known as HEB, functions as an oncogene as well as a tumor suppressor in several human cancer types [41]. The gene discussed is ESR1; the disease is cancer.