It was demonstrated that B. coagulans decreased the TNF-α similarly to indomethacin in an experimental rat model of rheumatoid arthritis [39], and B. clausii inhibited the secretion of proinflammatory cytokines (TNF-α, IL-6, IL-17) and increased levels of anti-inflammatory cytokines (IL-10) in a postmenopausal osteoporotic mouse model [40]. This evidence concerns the gene TNF and rheumatoid arthritis.