Most of our individuals’ last reported mood was depression, the pathophysiological relevance of KCNQ3 in suicide could be the result of a similar abnormality from the resilience studies, where downregulation in the DLPFC of individuals who die by suicide, may derive in an unstable neuronal resting potential that may have an impact on resilience, depression, and suicide. This evidence concerns the gene KCNQ3 and major depressive disorder.