INS and diabetes mellitus: Stress is one of the most relevant psychosocial factors in the development of diabetes; it affects blood glucose directly through neuroendocrine mechanisms (catecholamine, glucocorticoids, and inflammation biomarkers) that result in alterations in the production of hepatic glucose, insulin sensibility, and secretion [5,6], and maintains indirect action related to negative coping through disease risk behaviors [6,7].