The most common technique to induce cerebral aneurysms was surgical ligation of the CCA and/or the RA with concomitant induction of hypertension (64 studies), followed by CCA ligation without RA manipulation (24 studies) and elastase-induced creation of IAs in combination with corticosterone- or angiotensin II-induced hypertension (24 studies, see Table 2 for an overview of IA model by experimental animal). The gene discussed is AGT; the disease is hypertensive disorder.