For example, the disuse atrophy (denervation, casting, and tail suspension treatments) and the myostatin deficiency cause a slow-to-fast fiber-type shift [72,73], whereas the systemically muscle wasting (dexamethasone administration, cancer cachexia, and fasting treatments) and MOV treatment lead a fast-to-slow fiber-type shift [72,74]. Here, MSTN is linked to hyperinsulinemic hypoglycemia, familial, 4.