VEGFA and age-related macular degeneration: The visual prognosis of exudative AMD has been significantly improved by intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents [3], but the metabolic disturbances contributing to the dysfunction of the retinal pigment epithelium (RPE) and, secondarily, the loss of photoreceptors, remain poorly understood [4,5].