The intimate cross-talk between cancer cells and adipocytes resulted in the initiation of the process of adipocytes dedifferentiation in the sense of a reduction of adipocytes terminal differentiation with a reduction in the expression of differentiation markers such as PPARγ and C/EBPα as well as their downstream genes such as FABP4, ADIPOQ, and hormone sensitive lipase (HSL) [19,21]. This evidence concerns the gene LIPE and cancer.