Although some candidate molecules secreted by tumor cells such as tumor necrosis factor alfa (TNF-α) [36], Wnt3a [22], Wnt5a [37] and stromelysin-3 (MMP11) [38] have been proposed to dedifferentiate mature adipocytes, the precise mechanisms that could be involved in tumor-driven adipocyte dedifferentiation and lipid loss remain to be discovered. The gene discussed is TNF; the disease is neoplasm.