Furthermore, evaluating in a meta-analysis the relationship of adult weight gain with subgroups of BC, Vrieling at al. showed in obese patients a significantly increased risk of post-menopausal estrogen receptor (ER)+BC [summarized risk estimate (RE) = 2.33; 95% confidential interval (CI) 2.05–2.60] [48]. The gene discussed is ESR1; the disease is breast cancer.