UCHL1 and nasopharyngeal carcinoma: To validate the dysregulated methylation status of UCHL1, we performed bisulfite pyrosequencing analysis of cg07068756 (the most significantly hypermethylated CpG site ranked by p value; CpG islands and the bisulfite pyrosequencing region of UCHL1 are shown in Figure 1D) in normal and NPC tissue.