MethHC database analysis found that UCHL1 methylation level was significantly increased in colon adenocarcinoma, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, and bladder urothelial carcinoma Supplementary Figure S3B,C), negatively correlating with UCHL1 mRNA expression. This evidence concerns the gene UCHL1 and bladder transitional cell carcinoma.