KAT5 and Familial prostate cancer: To further examine whether RORα2-mediated activation of target genes is affected by RORα2 methylation that leads to increased binding to pontin/Tip60, mRNA expression levels of RORα2 target gene CTNND1, involved in the signaling of prostate cancer progression, were detected after the introduction of either RORα2 WT or the lysine methylation mutant, K87R (Figure 4C).