NFKB1 and cancer: On the other hand, several authors explain that polyphenols’ anticancer activity is due to their anti-inflammatory and antioxidant properties, mainly mediated by their ability to down-regulate the nuclear factor NF-kB, modulating crucial cell signaling pathways involved in inflammation and cancer, and subsequently reducing the expression of IL-8 signaling in lipopolysaccharide-stimulated CRC cells [85,86,87,88,90,92].