The 13 GFs, including E&F, MDK, PlGF, IL-6, PEDF, SHH, IGF1, TGF-β, neuregulin 1 (NRG-1), hepatocyte growth factor (HGF), PDGF and semaphorin 3A (Sema3A) have been linked to the aggressive phenotypes of gliomas, such as cell proliferation, survival, invasion, cancer stemness and the resistance to standard therapies [14,16,18,27,29,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84]. This evidence concerns the gene SEMA3A and central nervous system cancer.