To verify our findings in independent IDH1-wt glioblastoma cohorts, we first obtained the differentially expressed genes (DEGs) between E&F-dependent and -independent IDH1-wt GSCs in the GFSCAN cohort (Table S5), and then we defined the DEGs as surrogate markers to classify IDH1-wt glioblastomas with gene expression profiles into either the E&F-dependent or -independent groups. This evidence concerns the gene IDH1 and glioblastoma.