The 13 GFs, including E&F, MDK, PlGF, IL-6, PEDF, SHH, IGF1, TGF-β, neuregulin 1 (NRG-1), hepatocyte growth factor (HGF), PDGF and semaphorin 3A (Sema3A) have been linked to the aggressive phenotypes of gliomas, such as cell proliferation, survival, invasion, cancer stemness and the resistance to standard therapies [14,16,18,27,29,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84]. Here, IGF1 is linked to central nervous system cancer.