PTEN and glioblastoma: Recently performed large-scale studies reported that the genomic profiles of LGGs and glioblastomas are distinct; glioblastomas show frequent alterations in the epidermal growth factor receptor (EGFR), phosphatase and tensin homolog (PTEN), and cyclin-dependent kinase inhibitor 2A (CDKN2A), whereas genes encoding IDH1/2, ATRX, tumor protein P53 (TP53), capicua transcriptional repressor (CIC), and far upstream element binding protein 1 (FUBP1) are frequently altered in LGGs with or without 1p19q co-deletion [1,3,4,22].