IDH1 and neoplasm: Similarly, when we determined the tumor-intrinsic molecular subtypes of IDH1-wt GSCs based on gene expression profiles [28], IDH1-wt GSCs with a proneural subtype (n = 11) were more prevalent in the E&F-dependent group (10% (2/20) in E&F-independent vs. 34.6% (9/26) in E&F-dependent), while the tumor-intrinsic mesenchymal subtype (n = 16) was more dominant in the E&F-independent group (45% (9/20) in E&F-independent vs. 26.9% (7/26) in E&F-dependent) (Figure 4C).