However, DNMTi and HDACi are also capable of upregulating the expression of TAAs in different solid tumors [108,109,110,111], thus potentially sensitizing cancer cells to ICIs by upregulating CTLA4, PD-1, PD-L1, and PD-L2 molecules on both tumor cells and TILs [112,113]. Here, CD274 is linked to neoplasm.