Choroidal neovascularization (CNV) in the form of new vessels from the vascular choroid through Bruch's membrane into the retina accounts for most cases of severe visual disturbance because of AMD.3 Currently, intraocular injection of vascular endothelial growth factor (VEGF) neutralizing antibody is the first‐line treatment for CNV in wet AMD.4 However, some patients fail to respond to the treatment. This evidence concerns the gene VEGFA and wet macular degeneration.