ICAM1 and infection: Sublethal O. tsutsugamushi infection studies in outbred Swiss CD-1 mice [19], as well as clinical studies of human patients [20], have shown significant elevation of endothelial activation markers (ICAM-1, VCAM-1, E-Selectin, etc.)in the serum of infected individuals; however, endothelium-focused analyses during in vivo infection remain largely unexplored [21].