A wide array of importin α/β cargoes have been reported (Baade and Kehlenbach, 2019), including TDP-43, a nuclear DNA/RNA-binding protein that mislocalizes to the cytoplasm and forms pathologic aggregates in >97% of ALS cases (Neumann et al., 2006; Mackenzie et al., 2014). Here, TARDBP is linked to amyotrophic lateral sclerosis.