We and others have found evidence of NPC and NCT disruption in postmortem tissue and animal models of C9orf72-ALS, Alzheimer’s disease, and Huntington's disease, including mislocalization and loss of Nups and disruption of the Ran gradient (Zhang et al., 2015; Grima et al., 2017; Eftekharzadeh et al., 2018). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.