Until recently, studies of post‐translational modifications of HIF‐1α were expanded to hydroxylation,36 phosphorylation,37 methylation 38 and acetylation.39 In hepatocellular carcinoma, the homeobox protein PROX1 is overexpressed in hepatocytes and is required for cell migration. This evidence concerns the gene POU2F2 and hepatocellular carcinoma.