HIF1A and Hepatic fibrosis: Neovascularization exacerbates liver hypoxia and resistance to blood flow, which increases transcription of many hypoxia‐sensitive pro‐angiogenesis genes such as vascular endothelial growth factor (VEGF),4 platelet‐derived growth factor (PDGF) and angiopoietin.5 All these processes are regulated by the hypoxia‐inducible factor‐1α (HIF‐1α).6 Basic and clinical research also showed that inhibition of LSEC angiogenesis and HSC paracrine effects could alleviate liver fibrosis.5, 7