For example, high expression of Oct4 granted cells with ability of cells and associated with the formation of liver metastasis in CRC.[8] Many miRNAs were reported to effect on the stemness of CSC in CRC,[9] including miR-21,[10] miR146a,[11,12] mir-195-5p,[13] and so on. The gene discussed is POU5F1; the disease is colorectal carcinoma.