Chronic myeloid leukemia (CML) is a hematopoietic disorder characterized by a reciprocal t(9;22)(q34;q11) chromosomal translocation known as the Philadelphia (Ph) chromosome.[6] This abnormal chromosome translocation generates the BCR-ABL oncogene which is necessary (and sufficient) for the transformed phenotype of CML cells.Recently, many genes have been reported in hematological malignancies and play vital roles during clinical therapy. This evidence concerns the gene ABL1 and hematologic disorder.