Chronic myeloid leukemia (CML) is a hematopoietic disorder characterized by a reciprocal t(9;22)(q34;q11) chromosomal translocation known as the Philadelphia (Ph) chromosome.[6] This abnormal chromosome translocation generates the BCR-ABL oncogene which is necessary (and sufficient) for the transformed phenotype of CML cells.Recently, many genes have been reported in hematological malignancies and play vital roles during clinical therapy. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.