The EVI-1 gene located on the chromosome band 3q26 exhibits several oncogene-like properties and is activated in a subset of most myeloid neoplasms.[7] In acute myeloid leukemia, the expression level of EVI-1 gene has been associated with a poor prognosis, particularly in younger patients.[8,9] In addition, the activation of EVI-1 gene has also been reported in CML blast crisis, though less commonly in the chronic phase (CP).[10] The WT1 gene located on chromosome 11 encodes a zinc finger transcription factor that is involved in cell proliferation and differentiation. This evidence concerns the gene WT1 and acute myeloid leukemia.