ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Chronic myeloid leukemia (CML) is a hematopoietic disorder characterized by a reciprocal t(9;22)(q34;q11) chromosomal translocation known as the Philadelphia (Ph) chromosome.[6] This abnormal chromosome translocation generates the BCR-ABL oncogene which is necessary (and sufficient) for the transformed phenotype of CML cells.Recently, many genes have been reported in hematological malignancies and play vital roles during clinical therapy.