BCR and acute lymphoblastic leukemia: This suggests that STK4 insufficiency is critical in the pathogenesis of precursor lymphoblastic leukemia and mature lymphocyte neoplasms in humans.[8] Stk4-deficient mice exhibited reduced BCR signaling, which is related with defective BCR clustering and causes a defect in the differentiation of marginal zone and germinal center.[8] Interestingly, loss of STK4 in human leads to the imbalance in T-cell signaling and increased apoptosis and decreased count of T cells.[26]