TH and colorectal carcinoma: Since tyrosine hydroxylase (TH) has been used as a biomarker of adrenergic nerves (Faulkner et al., 2019), we divided the data into two groups, a group with Low TH RNA levels (representing CRC tumors with low adrenergic innervation) and a group with High TH RNA level, indicating highly adrenergically innervated CRC tumors.