In ITAS, there is a lower risk of hypoglycaemia (any definition) in both patient‐ and physician‐managed BI titration groups, likely because the insulin‐naïve population studied had lower hypoglycaemia risk, and also because Gla‐300 carries a lower risk of hypoglycaemia vs Gla‐100.13 The gene discussed is INS; the disease is Hypoglycemia.