SIRT1 and central nervous system cancer: EX-527 administered in rats as a single dose of 5 mg/kg i.p., 30 min prior to injection of 2-[18F]BzAHA caused almost a 2-fold inhibition of SIRT1 expression–activity in i.c. 9L gliomas, as evidenced by the comparison of baseline to posttreatment SUV and DV of 2-[18F]BzAHA.