First, increased survival in microbiologically-confirmed TBM patients randomised to high dose (1000 mg) adjunctive aspirin therapy was associated with a distinct shift in the pattern of arachidonic acid metabolites27, corroborating prior work by the same group that a polymorphism in the gene encoding leukotriene A4 hydrolase (LTA4H) influences both intracerebral inflammation and survival from TBM28, and also associates with corticosteroid responsiveness29. Here, LTA4H is linked to meningeal tuberculosis.