NLRP3 and diabetes mellitus: Many groups have reported that diabetes results in increased expression of genes that would be consistent with increased inflammation and with priming/and or activation of the NLRP3 inflammasome in both T1DM and T2DM (36, 37, 44, 58, 66, 104–109) (see the above section), but it is not yet clear what the diabetes signal that drives augmented NLRP3 activation might be.