Furthermore, SGLT2 inhibitors exert beneficial actions independent of glucose control, consistent with results from the recent DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) trial, which indicated beneficial effects of this SGLT2 inhibitor (dapagliflozin) in patients with heart failure and a reduced ejection fraction even when diabetes was not present (163). Here, SLC5A2 is linked to diabetes mellitus.